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    La thérapie par plasma riche en plaquettes peut aider les tendons et les ligaments blessés ainsi que d'autres problèmes musculo-squelettiques. Elle utilise des parties de votre propre sang pour réduire la douleur et accélérer la guérison. 

    Traitement par plasma riche en plaquettes (PRP)

     

     

    Comment se préparer?

    Se préparer à l'avance à une procédure PRP est une partie essentielle du processus. Veuillez lire la page Préparation de votre procédure régénérative de ce site Web pour obtenir des détails plus précis.

     

    Votre "sang total" est principalement composé de liquide (plasma) contenant des particules solides telles que des globules rouges, des globules blancs et des plaquettes, plus petites. Au cours d'une procédure PRP, une seringue de votre sang total est prélevée dans votre veine à l'aide de tubes PRP spéciaux, puis placée dans une centrifugeuse pendant deux cycles afin de séparer la couche de plasma qui contient une forte concentration de plaquettes.

     

    Les facteurs de croissance souhaitables et autres cytokines (molécules de signalisation cellulaire) utiles à la guérison sont associés aux plaquettes. Une fois que cette couche riche en plaquettes de votre propre plasma a été isolée, elle peut être réinjectée dans votre corps pour cibler une zone de lésions tissulaires dans les muscles, les tendons, les ligaments ou les articulations.

     

    La visualisation par ultrasons est utilisée pour augmenter la précision, la sécurité et le confort de l'injection sans exposition aux radiations. Toutes les injections de PRP sont effectuées dans notre cabinet pour votre commodité, afin que vous n'ayez pas à vous rendre dans un hôpital ou un centre de chirurgie ambulatoire. Nous vous invitons à prendre rendez-vous avec nous pour savoir si la thérapie PRP peut vous aider.

     

    Les athlètes qui souffrent de douleurs chroniques dues à des blessures aux tendons peuvent enfin être soulagés grâce à une procédure sûre et non chirurgicale. Il s'agit de la thérapie par plasma riche en plaquettes (PRP), qui utilise les plaquettes sanguines des athlètes pour reconstruire un tendon endommagé. 

     

    Il a réussi non seulement à soulager la douleur, mais aussi à amorcer le processus de guérison. Le problème Les tendons sont des structures en forme de cordon qui relient les muscles aux os, permettant à ces derniers de bouger. Lorsqu'un tendon est blessé pour la première fois, il peut devenir enflammé, gonflé et douloureux. Cette blessure est souvent ressentie par les athlètes de tennis, de baseball, de football et de tout autre sport nécessitant des mouvements de lancer répétitifs. Cependant, la plupart des douleurs chroniques aux tendons ne sont pas dues à une inflammation importante, car le tissu lui-même commence à se dégrader. C'est pourquoi les traitements traditionnels comme le repos, la glace et les anti-inflammatoires ne procurent souvent pas de soulagement durable. Pendant des années, le dernier recours a été pour un chirurgien d'essayer de retirer le tendon endommagé, avec un succès variable.

     

    La solution de la thérapie par plasma riche en plaquettes (PRP) a récemment été introduite dans l'arsenal de l'Emory Sports Medicine. La procédure est réalisée dans une salle d'examen et dure moins d'une heure. Le sang du patient est prélevé à l'aide de tubes PRP et placé dans une centrifugeuse pendant 15 minutes pour séparer les plaquettes. La couche de plasma riche en plaquettes est ensuite injectée dans la partie malade du tendon, sous la conduite d'un appareil à ultrasons. Récupération après la thérapie par PRPI Les patients suivent un programme de repos relatif suivi d'une thérapie physique pendant les 6 premières semaines. Après environ 6 à 12 semaines, les patients sont réévalués pour voir si leur état s'améliore. Certains patients présentant des blessures plus difficiles peuvent avoir besoin de plus d'un traitement pour obtenir des résultats positifs.

     

    La thérapie par plasma riche en plaquettes (PRP) est une procédure non chirurgicale proposée par les médecins du Gelb Sports Medicine and Orthopaedic Center. Cette procédure moderne a fait l'objet d'une attention accrue dans le monde de la médecine sportive ces derniers temps, car un certain nombre d'athlètes professionnels de haut niveau, dont Kobe Bryant, Rafael Nadal et Alex Rodriguez, ont opté pour le PRP pour les aider à se remettre de leurs blessures. Les personnes souffrant de blessures liées aux tendons, comme celles du coude, de l'épaule et du genou, peuvent être candidates à un traitement PRP, tout comme les personnes souffrant d'arthrose et d'autres maladies dégénératives.

     

    Le processus PRP

    Un élément attrayant de la thérapie par plasma riche en plaquettes est que le patient est traité avec son propre sang, il est donc peu probable que l'organisme rejette le traitement. Le processus commence par le prélèvement d'une petite quantité de sang sur le patient. Les plaquettes sanguines sont ensuite séparées des globules rouges et blancs par un processus appelé centrifugation - la séparation se produit sous l'effet de la force centripète appliquée. Une fois séparé des autres cellules sanguines, on extrait le plasma qui contient une forte concentration de plaquettes. Les plaquettes sont surtout connues pour leur rôle important dans la coagulation du sang, mais elles contiennent également de grandes quantités de protéines bioactives, notamment des facteurs de croissance qui sont utiles à la réparation, à la récupération et à la régénération des tissus. Le plasma riche en plaquettes est ensuite injecté directement dans la zone de la blessure.

     

    Traitement par PRP

    Le traitement par PRP peut s'appliquer aux patients jeunes et moins jeunes. Le plasma riche en plaquettes peut être utilisé pour aider le corps à guérir après une intervention chirurgicale ou employé pour traiter des blessures qui ne nécessitent pas de chirurgie. La thérapie PRP est utile pour traiter un certain nombre de blessures liées au sport. Les blessures de surmenage des lanceurs de baseball, le tennis elbow et un certain nombre de blessures articulaires liées au stress et aux traumatismes peuvent bénéficier de la thérapie PRP. Bien que les applications de la thérapie par plasma riche en plaquettes soient extrêmement prometteuses, la procédure n'est pas recommandée pour toutes les blessures en général, mais est envisagée et recommandée au cas par cas.

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  • From basic science to clinical applications

     

    For two decades, platelet-rich plasma (PRP) has been used in surgery to treat sports injuries. PRP contains growth factors and biologically active proteins that help in the healing of damaged tendons, ligaments, muscles and bones. This article highlights the current scientific knowledge of OLP and describes its application in sports medicine.

    Research into the biology of bone, ligament and tendon regeneration has led to the development of various products designed to help stimulate biological factors and promote healing. The use of autologous and recombinant products has rapidly expanded the ability of orthopedics to manipulate growth factors and secretory proteins to improve bone and soft tissue healing. But they are not used in the clinic, because many of these products have not been tested using rigorous scientific standards.

    Platelet-rich plasma (PRP) is one such example. This autologous product was first used and researched in the 70s of the last century. The healing properties of PRP have been used in clinical practice to increase the concentration of autologous growth factors and secretory proteins, which could enhance the regeneration processes at the cellular level. It is hoped that PRP enhances the recruitment, proliferation, and differentiation of cells involved in tissue regeneration. In the literature, PRP products, also known as PRP, platelet-rich concentrate, platelet gel or growth factor-rich preparation, have been investigated in in vitro and in vivo experiments in the field of maxillofacial and general surgery. Moreover, In orthopedic work, the role of PRP in the healing process of muscles and tendons has been investigated and it is becoming increasingly known to the general public. In February 2009, an article was published in the New York Times about treating an injury with a famous football player's OTP. Although there are numerous scientific studies.

    The use of OLT and related research in sports medicine and orthopedic surgery is not standardized and is mostly sporadic based on small case series (LE 4). Before introducing the OTP technique into the practice of sports medicine, it is necessary to evaluate the literature that supports the safety and effectiveness of this technique.

     

    Scientific knowledge of platelet-rich plasma

     

    What is OTP?

    Platelets are small, non-nuclear blood elements that play a major role in the processes of hemostasis. Platelets contain a variety of proteins, cytokines, and other bioactive factors that stimulate and regulate major links in injury healing. The normal number of platelets in the blood is in the range of 150,000 - 300,000 per microliter of whole blood. Plasma is the liquid part of the blood that contains clotting factors, other proteins and ions. Platelet-rich plasma is plasma containing about 1,000,000 platelets per microliter of plasma. PRP Tubes 3-5 times more growth factors than whole blood.

    Bioactive factors of PRP

    Platelet-rich plasma has the potential to improve healing through various growth factors and cytokines secreted from platelet α-granules. Major cytokines found in platelets include transforming growth factor β (TGF-β), platelet growth factor (PDGF), insulin-like growth factor (IGF-I, IGF-II), fibroblast growth factor (FGF), epidermal growth factor, growth factor vascular endothelium (VEGF) and endothelial cell growth factor. These cytokines play an important role in the processes of cell proliferation, chemotaxis, differentiation, and angiogenesis (Table 1).

     
    Table 1 - Growth factors found in platelet-rich plasma and their physiological effects
    Factor Target Functions
    PD-EGF Blood vessel cells, outer skin cells, fibroblasts, and many other cell types Cell growth, recruitment, differentiation, skin wound closure, cytokine secretion
    PDGF A + B Fibroblasts, smooth muscle cells, chondrocytes, osteoblasts, mesenchymal stem cells Strong cell growth, recruitment, blood vessel growth, granulation, secretion of growth factors, collagen matrix formation  and bones involving bone morphogenetic proteins (BMP)
    TGF-β1 Blood vessel tissue, outer skin cells, fibroblasts, monocytes, TGF class including BMP, osteoblasts - highest level of TGF-βr Blood vessels (±), collagen synthesis , growth inhibition, apoptosis , differentiation, activation
    IGF-I, II Bone, blood vessels, skin, and other tissues; fibroblasts Cell growth, differentiation, recruitment, collagen synthesis with the participation of PDGF
    VEGF, ECGF Blood vessel cells Cell growth, migration, growth of new blood vessels c, antiapoptosis
    bFGF Blood vessels, smooth muscle, skin, fibroblasts, and other cell types Cell growth, cell migration, blood vessel growth
    PD-EGF - epidermal platelet growth factor, PDGF - platelet growth factor, BMP - bone morphogenetic protein, TGF - transforming growth factor, IGF - insulin-like growth factor, VEGF - vascular endothelial growth factor, ECGF - endothelial cell growth factor, bFGF - basic fibroblast growth factor.

     

    Biologically active factors of platelets are also contained in their dense granules. They contain serotonin, histamine, dopamine, adenosine and calcium ions. These factors are not growth factors, but they also play a fundamental role in the healing process. There are 3 stages of healing: inflammation, proliferation and reconstruction. The stage of inflammation begins immediately after injury, as a result of which platelets are activated, aggregate and secrete growth factors, cytokines and hemostatic factors necessary in the early stages of coagulation processes. Histamine and serotonin released by platelets activate macrophages and increase vascular permeability, which opens access to the focus of inflammation. Polymorphonuclear leukocytes migrate to the area of ​​inflammation and soon after, the cells begin to grow, while fibroblasts help to form the base substance. Through the activation of adenosine receptors, the regulation of inflammation and damage healing occurs (Tables 2 and 3).

     

      
    Table 2 - Biologically active molecules contained in platelet α-granules
    Factor categories Specific molecules Biological action
    Growth factors TGF-β Stimulates Matrix Synthesis
    PDGF Cell adhesion to the surface of chemoattractants, cell proliferation
    IGF-I, II Cell proliferation, maturation, bone matrix synthesis
    FGF Angiogenesis, fibroblast proliferation
    VEGF Cell proliferation
    EGF Angiogenesis
    ECGF Endothelial cell proliferation, angiogenesis
    Adhesive proteins Fibrinogen Blood clotting cascade (fibrin clot formation)
    Fibronectin Binding to integrins on the cell surface, effects on cell adhesion, cell growth, migration and differentiation
    Vitronectin Cell adhesion, chemotaxis
    Thrombospondin-1 Inhibition of angiogenesis
    Clotting factors Factor V, factor XI, protein S, antithrombin Everyone takes part in the activation of thrombin and, as a result, in the formation of a fibrin clot
    Fibrinolytic factors Plasminogen Plasmin precursor that breaks down fibrin
    Urokinase inhibitor Regulation of plasmin production
    α-2 antiplasmin Plasmin inactivation
    Proteases and antiproteases TIMP-4 Regulation of matrix degradation
    Metalloproteinase-4 Decomposition of the matrix
    α-1 antitrypsin Inhibition of a wide range of enzymes and proteinases
    Basic proteins Platelet factor 4 Inhibition of angiogenesis
    β-thromboglobulin Platelet activation, inhibition of angiogenesis
    Endostatin Inhibitors of endothelial cell migration and angiogenesis
    Membrane glycoproteins CD40 ligand Inflammation, synthesis of interleukins and integrins, adhesion of platelets to the endothelium, cellular signaling, modulation of interleukin-activated molecule-1 (PECAM-1) on leukocytes
    P-selectin Vascular endothelial adhesion molecule, assists in the binding and recruitment of leukocytes in the area of ​​inflammation
    TGF - transforming growth factor, PDGF - platelet growth factor, IGF - insulin-like growth factor, FGF - fibroblast growth factor, EGF - epidermal growth factor, VEGF - vascular endothelial growth factor, ECGF - endothelial cell growth factor, TIMP-4 - tissue inhibitor metalloproteinase-4.

     

    Table 3 - Biologically active molecules contained in dense granules of platelets
    Molecules Biological action
    Serotonin Vasoconstriction, increases capillary permeability, attraction of macrophages
    Histamine Increases capillary permeability, attraction and activation of macrophages
    Dopamine Regulation of heart rate and blood pressure, neurotransmitter
    ADP Induces platelet aggregation
    ATF Takes part in the reaction of platelets when they interact with collagen
    Ca 2+ Cofactor for platelet aggregation and fibrin formation 
    Catecholamines Sympathomimetic hormones are secreted by the adrenal glands in response to stress
    ADP - adenosine diphosphate, ATP - adenosine triphosphate.

    Platelets in PRP participate in thrombus formation, which contains a variety of cell adhesion molecules, including fibronectin, fibrin, and vitronectin. These molecules play an important role in the processes of cell migration and are of interest in the study of the bioactive properties of PRP. The blood clot itself may also play a role in the healing of the damage.

     

    Obtaining OTP

    Platelet-rich plasma can only be prepared from non-clotted blood. It cannot be prepared from clotted whole blood, from which serum is usually obtained, because most of the platelets remain in the resulting clot. Also, PRP cannot be prepared from serum, which is a clear liquid obtained from whole clotted blood and freed from cells and proteins involved in the clotting process. Serum contains very few platelets. For the preparation of PRP, blood is taken into a container with sodium citrate, which binds calcium ions, thereby blocking the entire coagulation cascade. This is followed by the centrifugation stage, which is carried out in one or two stages. In the first centrifugation, plasma and platelets are separated from red blood cells and white blood cells. Erythrocytes (7 microns in diameter) and leukocytes (7-15 microns in diameter) are much larger and heavier than platelets (2 microns in diameter) and are easily separated. The second centrifugation is carried out more gently and, as a result, OTP is concentrated; platelet-poor plasma remains in the supernatant.

    The next important step is the activation and aggregation of platelets, leading to the release of all biologically active factors contained in platelets. Several commercially available PRP systems use bovine thrombin as a clotting agent. In 10 minutes, about 70% of the bioactive factors contained in them are released from platelets, and in 1 hour almost 100%. However, the use of bovine thrombin can lead to complications associated with the formation of antibodies against it. This complication is very unlikely, but it is potentially possible and can lead to such a serious disease as immune-mediated coagulopathy. Also clots formed by thrombin show significant retraction.

    An alternative way to activate platelets is the use of a "fibrin matrix". The fibrin matrix is ​​formed from autologous fibrin , which is formed from fibrinogen under the action of its own thrombin, which is formed as a result of the addition of calcium chloride (CaCl2) to PRP. Calcium chloride is added before the second centrifugation, resulting in a dense fibrin matrix. Intact platelets interact with the formed fibrin network and are activated. This PRP activation technique is characterized by a low level of thrombin generated and, thus, minimization of platelet activation. As a result, platelets release growth factors rather slowly, and this process can take up to 7 days.

    The third way to activate PRP is the use of type II collagen . Collagen has been shown to be as effective as thrombin in stimulating platelet release of PDGF and VEGF growth factors. On the other hand, collagen- assisted clots are less retracted than thrombin- assisted clots .

     

    Effect of PRP on tissues

    Connective tissues such as tendons, ligaments, and muscles heal in three phases: inflammation, proliferation, and reconstruction. Various cytokines are actively involved in all of these phases. Cytokines play a major role in damage healing by interacting with transmembrane receptors on local and circulating cells, initiating intracellular signaling, which ultimately affects gene expression in the nucleus. As a result of this expression, proteins appear that regulate cell proliferation, cell chemotaxis, angiogenesis, cell differentiation, and extracellular matrix formation. It is known that cytokines and other biologically active factors isolated from PRP affect the main metabolic processes in the soft tissues of the musculoskeletal system, including tendons, ligaments and muscles.

    The effect of PRP on tendons. When evaluating the role of OLT in tendon repair, it is important to distinguish between acute injury and chronic tendinitis. ... Several recent studies have clearly shown that PRP positively influences gene expression and matrix synthesis in tendons and their cells. Incubation of cultured human tenocytes with PRP increases their proliferation and the total synthesis of collagen increases, slightly increases the expression of such enzymes of degradation of the extracellular matrix as metalloproteinase-1 and 3. the strength and rigidity of tendon callus (callus).

    The effect of PRP on muscles. Several cytokines contained in PRP have a positive effect on the healing of damaged muscles. For example, in a model of rupture of the gastrocnemius muscle in mice, basic fibroblast growth factor (bFGF) and IGF-I improve muscle healing. Autologous serum administered 2, 24, or 48 hours after injury to the gastrocnemius muscle in mice accelerated concomitant cellular activation and increased the diameter of the myofibril regeneration zone.

     

    Clinical use of platelet-rich plasma

     

    The literature has accumulated a large amount of data on the clinical use of OLT in such areas as maxillofacial surgery, otolaryngology, plastic surgery and general surgery.

     

    This article is a partial translation of an article by Timothy E. Foster, Brian L. Puskas, Bert R. Mandelbaum, Michael B. Gerhardt, and Scott A. Rodeo - Platelet-Rich Plasma: From Basic Science to Clinical Applications from The American Journal of Sports Medicine - November 2009 37: 2249-2251. From the original article, you can learn about the clinical use of PRP for injuries such as lateral epicondylitis and other tendinopathies of the elbow , tendinopathies of the Achilles tendon, patella , treatment of fractures, osteoarthritis , acute injuries of ligaments and muscles ; use of PRP during operations for reconstruction of the anterior cruciate ligament , restoration of the Achilles tendon, rotator cuff of the shoulder, articular cartilage . And you will also read detailed practical recommendations on the preparation method and the procedure for introducing PRP.


  • Platelet Rich Plasma, or PRP, is blood filled with platelets. Serum (blood plasma is a liquid part of blood, composed mainly of water) for treatment is obtained by centrifuging the blood of the person performing the treatment. In this way, other blood components, leukocytes and erythrocytes are removed, and the serum prepared in this way has 5 to 10 times more platelets than is usual in the blood. They cause coagulation - blood clotting and contain proteins that help wounds to heal.

    PRP serum contains growth factors, e.g. platelet-derived growth factor (PDGF-AA, BB or AB), insulin-like growth factor (IGFI and II), transforming growth factor beta (TGF-b), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), fibroplast growth factor (FGF 1 and 2). There are also bone morphogenetic proteins (BMP, especially BMP12 and BMP 13).

    Growth factors can be locally produced by the cells in the area of ​​the injury, they can reach the bloodstream or during physiological repair. They have long been known to be modulators of cell growth and development, to influence migration, replication, matrix synthesis and cell transformation. They have a positive effect on various stages of healing of muscles, ligaments and tendons and accelerate the healing of wounds on the skin and subcutaneous soft tissues.

    This therapy uses the body's natural ability to heal. When we cut ourselves, for example, the body's defensive reaction is to attract platelets to that place and thus speed up the wound healing process. The treatment has been used in medicine for more than 30 years, especially in orthopedics and cardiology, and as a form of rejuvenation since 2005.

    What problems are treated with PRP?

    PRP is applied when it is necessary to stimulate faster recovery and tissue regeneration. In aesthetic medicine, in degenerative problems with joints, in the treatment of chronic wounds, in injuries of the musculoskeletal system. Doctors initially used PRP to help people recover after jaw surgery and after plastic surgery. Tissues on which PRP has been used include tissues of tendons, ligaments and muscles. Ligaments take a long time and can be difficult to recover, so PRP is a good choice for those who have experienced an injury to that group of tissues.

    How is it performed?

    It all starts with an examination by a specialist doctor and after that he draws some of the patient's blood from which the serum is made. It contains active substances that stimulate platelets to release growth factors. Such a serum is applied to the skin with the mesotherapy technique with very thin needles.

    Is it safe?

    PRP treatment is safe because the patient's own blood is used and there are no immunobiological barriers to the risk of allergic reactions and transmissible diseases. Unlike corticosteroid injections, there is no risk of local tissue weakening and consequent ruptures of tendons, ligaments and muscles.

    After application, short-term pain, redness and swelling are possible. The PRP method is not an omnipotent therapy that gives 100% results, but, applied in the right way, it is completely safe and without side effects. For the success of the therapy, it is necessary to prepare the PRP serum in the right way and apply it in the right indications. So to evaluate the application of orthopedic PRP treatment, it is best to contact experienced doctors.

    How long does the treatment last?

    It takes from fifteen minutes to half an hour from the blood draw to the application of the serum with prp tubesIf the procedure is more complex, then longer. After that, the patient can go immediately, it's that simple. Up to ten days after application, platelets release growth factors. They lead to better hydration and blood circulation of the skin, it is nourished and receives more oxygen. The treatment improves the complexion, tone, color and texture of the skin. Although it is known by the names "Draculin" or "Vampire treatment", it is recommended for people who want to avoid aggressive treatments. Also, if you have acne scars, you want to remove wrinkles and put aging skin under control.

    Who is recommended for treatment and who is not?

    Absolute contraindications for the use of PRP treatment are:

    • malignant diseases
    • acute infections
    • systemic blood diseases

    Relative contraindications for the use of PRP treatment are:

    • use of corticosteroids 4-6 weeks before intervention
    • anticoagulant therapy
    • surgery a month before the procedure
    • autoimmune diseases of the musculoskeletal system
    • use of anti-inflammatory drugs one week before treatment (aspirin, diclofenac ()
    • chronic kidney and liver disease

    PRP: Instructions for behavior before the procedure

    Before the therapy, the doctor will instruct you on what awaits you during the treatment. Anyway, you should remember a few things.

    At least 3 to 4 days before therapy, stop taking anti-inflammatory drugs (NSAIDs - nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen…, etc.)

    One to two weeks before your procedure, stop using blood-thinning herbs, various supplements or vitamins.

    Stop using systemic steroids one to two weeks before your procedure.

    Stop using steroid injections at least a month before your procedure.

    On the day of your treatment, eat a hearty breakfast of healthy food and be sure to drink plenty of water

    If you are taking chronic oral steroids, it is advisable to consult your doctor about abruptly stopping taking them as this can lead to side effects. If you are taking any medications, consult with the person who prescribed them.

    How to behave after PRP treatment

    After PRP therapy, resting throughout the day is recommended. In the next two days, limited use of the part of the body in which the injection was received is recommended. But, movement is also advised, because it helps the joint to recover - the injection is adopted in the tissue that surrounds the injection site.

    0 to 3 days after injection

    After the treatment, there is a possibility that you will feel mild to moderate pain in the treated area. This is a normal sign that your body is recovering and adapting to the injection. It is best to drink plenty of water to facilitate recovery.

    It is very important that you do NOT take ANY medications after the procedure unless your doctor recommends it. This is because any drug can affect the recovery process and have various side effects.

    Therefore, stop taking any of these medications after treatment so that you can get the best possible results:

    Do not take anti-inflammatory drugs for at least two weeks after treatment (aspirin, diclofenac, ibuprofen ()

    Do not take herbs that dilute blood, supplements or vitamins for at least 3-4 days after treatment

    Systemic steroids for at least two weeks after treatment

    Other important instructions to follow after your treatment are:

    Do not put ice on the injection site for at least 72 hours

    Do not bathe in hot water or go to the sauna for the first few days after the treatment

    Do not consume any alcoholic beverages for at least a week after treatment

    Do not shower for the first 24 hours

    Avoid smoking

    Instructions for behavior of 3-14 days:

    In this part of your recovery, you should gradually increase your daily activities. Now you can start with the exercises. Proper exercise is the key to long-term results and you should consult a doctor about the ones that would suit you best before PRP therapy itself.

    Ice can be applied three to four times a day for 15-20 minutes if you feel the need.

    Anti-inflammatory drugs can be taken as directed to relieve any residual pain.

    Still avoid alcohol, smoking or excessive amounts of caffeine

    Instructions for behavior 3-4 weeks after treatment

    At this point in your recovery, it is advisable to start physical therapy to make your recovery effective in the long run. Now is the time to see a doctor who will assess the progress of your recovery. It is important to do this even if your recovery is going great. If something needs to change in your treatment plan, there is a time when your therapist will be able to assess it.

    PRP therapy in orthopedics

    PRP therapy has proven to be an excellent type of treatment for numerous conditions and injuries of the knees, hips, shoulders, elbows, joints, cartilage, tendons and ligaments.

    We will try to explain why PRP might not work and how just one injection will lead to unsatisfactory long-term results.

    There are many treatments for pain in e.g. knee. Cortisone injections, hyaluronic acid and "gel" injections. But cortisone injections, although they cause immediate relief in most people, are not without danger. The harmful properties of corticosteroids have long been known in medicine. It is generally given when the patient needs to prepare for joint replacement. Cortisone only reduces the pain caused by chronic inflammation. And nothing heals. PRP leads to recovery despite inflammation. When the tissue regenerates, the inflammation disappears.

    Cortisone is a short-term solution, and PRP is a long-term solution. Cortisone will eventually suppress the body's natural power and lead to knee replacement. PRP will rebuild and recover the tissue in the knee and help you avoid knee replacement or arthroscopic surgery.

    A single use of PRP therapy causes an inflammatory response, while a cortisone injection causes a completely opposite, anti-inflationary effect. People here are often confused when the inflammation gets worse after PRP therapy and then say that they know that PRP does not work. And it is very difficult to fix what has been accumulating over the years with one injection. Degenerative disease does not occur during the night, nor does its cure.

    Doctors say, after the experience of working on thousands of patients, that PRP is much less effective as a 1-dose treatment. They realized that it was much more successful as a multi-dose program. They see PRP treatment in cooperation with Prolotherapy (technique 1 injection of hyper dextrose) as a solution for strengthening the hip ligaments and its stability.

    According to their experience, when someone has a degenerative disease of the hip and the cartilage wears out and disappears, you simply cannot fix the condition with the cartilage without seeing what causes its damage. This is erosion or irreparable joint damage that you have probably heard about many times. This manifests as instability in the hip, with the feeling that your hip is shaky, loose and insecure.

    Prolotherapy uses hypertonic dextrose, in addition to some other simple ingredients that are individualized for each person, in order to initiate localized soft tissue regeneration. For the hip, the treatment is used to repair, tighten and strengthen the ligament that holds the hip bones in place.

    Doctors often use PRP to treat hip pain and restore its function and range of motion. During the treatment, they clean the skin from your hip and use ultrasound to see inside your body. This helps them guide the needle. The goal is to inject the PRP infusion directly into the injured part of the hip. The whole process takes 45 to 90 minutes. After the procedure, you may feel pain in your hip and the doctor may give you crutches to relieve it.

    Magnetic resonance evidence that PRP rebuilds cartilage

    A January 2020 study, published in the Journal of Pain Research , investigated the effect of PRP therapy on cartilage characteristics through special magnetic resonance imaging of patients with osteoporosis of the knee. All patients were women about 58 years of age.

    It was a study of 46 knees from 23 patients.

    23 knees were in the control and 23 in the group that received PRP therapy.

    In the PRP group, all radiological variables (patellofemoral cartilage volume, synovitis, and medial and lateral meniscus disintegration) with the exception of subarticular bone marrow abnormalities, had significant improvements. In a comparison of the two groups, patellofemoral cartilage volume and synovitis changed significantly in the PRP group.

    The University of California in the “ Tissue Building ” study claims that PRP injections cause positive healing cell changes in the joint environment. These changes help the knee to move from a degenerative to a recovered and regenerated state of the joint environment. Healing involves the regeneration of articular cartilage, increasing the amount of natural knee lubricants, and awakening existing stem cells in the knee that help transform them into a healthy environment.  

    In that study, the researchers wrote: PRP modulates the repair and regeneration of damaged articular cartilage in the joints and delays cartilage degeneration by stimulating the migration and proliferation of stem cells and their differentiation into cartilage cells.

    In addition, PRP reduces pain by reducing inflammation of the synovial membrane, and pain receptors are located there. The synovial membrane is a protective layer of connective tissue that is also responsible for creating a synovial fluid that lubricates the joints.

    That said, PRP injections really help reduce knee pain and restore function in patients with osteoarthritis.

    LASER AND PRP THERAPY

    If you do not like needles, you can decide to perform the procedures in combination with laser rejuvenation. The effect of these two methods gives a strong effect because it combines the effect of stimulating regeneration with the help of blood plasma and laser rejuvenation.

    The laser makes micro-holes in the skin into which the blood serum is placed. It is certainly more comfortable for the patient. This combination is also good for removing scars. Also, PRP gives excellent results in combination with hyaluronic fillers. Laser therapy and PRP are also used in combination with mesotherapy to rejuvenate and remove scars. They also significantly contribute to slowing down skin aging. Laser and PRP use the cumulative effect of both methods in removing acne scars. Laser peeling evens out the skin, achieves the formation of new collagen, and in addition has an anti-inflammatory and regenerative effect, so it improves the quality of the skin. The PRP method additionally uses the production of collagen, so after the treatment, the structure of the skin is improved, the indentations are filled, that is, new, young tissue is created.

    User experiences

    Many top athletes (eg Tiger Woods , golf champion) are happy to resort to PRP therapies in order to get in competitive shape as soon as possible after injuries and painful conditions. It is often combined with arthroscopy of the knee, shoulder or ankle in sports injuries. It should be noted that under current regulations, the WORLD ANTI-DOPING AGENCY (WADA) PRP is permitted and is not on the doping list. But, you probably belong to ordinary people, so it can be thought with some certainty that you do not belong to those who dream of an Olympic medal.

    Research studies on PRP include:

    One was published in 2015 in Stem Cells Translational Medicine and it is claimed that people who had the treatment sprouted more hair of much higher density than those who did not. However, the study included a small group of only 20 people.

    Another, published in 2013, in the American Journal of Sports Medicine , found that PRP injections reduced pain in osteoarthritis of the knee compared to salt injections. The study again included a relatively small number of 78 participants.

    An article published in 2014, again in the American Journal of Sports Medicine , confirmed that three rounds of PRP injections reduced symptoms in people with chronic patellar tendinopathy of the knee. The researchers used 28 athletes in the study.

    General about PRP treatment

    PRP treatment is absolutely safe. Plasma obtained from the patient's blood is used, so there is no danger of allergic or immune reactions of the organism. So there are no limits when it comes to the number of injections that can be obtained within a year.

     

    What about recovery time? If you lead an active, working life (like most people), then you may not be able to devote enough time to recovery. The great thing about PRP injections is that the recovery time is short. Studies have shown that the positive effects of injections can improve the quality of life and reduce pain for patients suffering from osteoporosis, not to mention the quality of life of people who came for other, aesthetic reasons.


  • A complex formulation based on lactoferrin, aloe and hyaluronic acid, fully consolidates the aesthetic treatment result. 

    Lactoferrin cream helps against bruising and bruises.

    Lactoferrin cream intervenes in the removal of redness and skin dyschromia after aesthetic treatment. A complex of active ingredients contributes to the resolution of ecchymosis and hematomas in the post treatment.

    #lactoferrin #blaueflecken #bluterguss #bruises #bruising #aesthetic #aesthetics #aestheticedit #aestheticedits #prptreatment #prp #prpfacial #prpinjection #prpseats #plateletrichplasma #prpbehandlung #medicine #medicinestudent #medizin #skin #beauty #health

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